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Plaquenil is often prescribed once per week, so it is advised to choose a day on which you would like to take the tablet every week. It is advised to take this medicine with a proper meal or a glass full of milk. To prevent malaria: Start taking Plaquenil 2 weeks before entering an area where malaria is common. Continue taking the medicine regularly during your stay and for at least 8 weeks after you leave the area.

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